Biosynthesis of DPAn-3-derived protectins and resolvins

Hansen TV, Dalli J, Serhan CN. The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions. Prostaglandins & Other Lipid Mediators. 2017 Nov;133():103–10. doi: 10.1016/j.prostaglandins.2017.06.003.; Vik A, Dalli J, Hansen TV. Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid. Bioorganic & Medicinal Chemistry Letters. 2017 Jun;27(11):2259–66. doi: 10.1016/j.bmcl.2017.03.079.; Dalli J, Colas RA, Serhan CN. Novel n-3 Immunoresolvents: Structures and Actions. Scientific Reports. 2013 Jun 05;3(1):1940. doi: 10.1038/srep01940.; Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G, Moussignac RL. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med. 2002 Oct 21;196(8):1025–37. PMID: 12391014; PMCID: PMC2194036.

Metabolites

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.13.11.-
1.13.11.12 linoleate 13S-lipoxygenase linoleate:oxygen 13-oxidoreductase
1.13.11.31 arachidonate 12-lipoxygenase arachidonate:oxygen 12-oxidoreductase
1.13.11.33 arachidonate 15-lipoxygenase arachidonate:oxygen 15-oxidoreductase


Proteins

Protein ID name full name