Formation of the Early Elongation Complex
Yamaguchi Y, Inukai N, Narita T, Wada T, Handa H. Evidence that Negative Elongation Factor Represses Transcription Elongation through Binding to a DRB Sensitivity-Inducing Factor/RNA Polymerase II Complex and RNA. Molecular and Cellular Biology. 2002 May 01;22(9):2918–27. doi: 10.1128/mcb.22.9.2918-2927.2002.; Conaway JW, Shilatifard A, Dvir A, Conaway RC. Control of elongation by RNA polymerase II. Trends Biochem Sci. 2000 Aug;25(8):375–80. doi: 10.1016/s0968-0004(00)01615-7. PMID: 10916156.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.7.11.23 | [RNA-polymerase]-subunit kinase | ATP:[DNA-directed RNA polymerase] phosphotransferase | |
| 2.7.7.6 | DNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) | |
| 3.1.3.16 | protein-serine/threonine phosphatase | protein-serine/threonine-phosphate phosphohydrolase | |
| 5.6.2.3 | DNA 5'-3' helicase | DNA 5'-3' helicase (ATP-hydrolysing) | |
| 5.6.2.4 | DNA 3'-5' helicase | DNA 3'-5' helicase (ATP-hydrolysing) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| O13768 | ptr8 | General transcription and DNA repair factor IIH helicase/translocase subunit XPB |
| P26659 | rad15 | General transcription and DNA repair factor IIH helicase subunit XPD |
| P36594 | rpb1 | DNA-directed RNA polymerase II subunit rpb1 |
| Q02061 | rpb2 | DNA-directed RNA polymerase II subunit RPB2 |
| Q12126 | crk1 | Serine/threonine-protein kinase crk1 |
| Q9P376 | fcp1 | RNA polymerase II subunit A C-terminal domain phosphatase |