Role of LAT2/NTAL/LAB on calcium mobilization

Orr SJ, McVicar DW. LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes? J Leukoc Biol. 2011 Jan;89(1):11–9. PMID: 20643813; PMCID: PMC3004523.; Iwaki S, Spicka J, Tkaczyk C, Jensen BM, Furumoto Y, Charles N, Kovarova M, Rivera J, Horejsi V, Metcalfe DD, Gilfillan AM. Kit- and Fc?RI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells. Cellular Signalling. 2008 Jan;20(1):195–205. doi: 10.1016/j.cellsig.2007.10.013.; Dráberová L, Shaik GM, Volná P, Heneberg P, Tumová M, Lebduska P, Korb J, Dráber P. Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker. J Immunol. 2007 Oct 15;179(8):5169–80. doi: 10.4049/jimmunol.179.8.5169. PMID: 17911602.; Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T. LAT and NTAL Mediate Immunoglobulin E-Induced Sustained Extracellular Signal-Regulated Kinase Activation Critical for Mast Cell Survival. Molecular and Cellular Biology. 2007 Jun 01;27(12):4406–15. doi: 10.1128/mcb.02109-06.; Volná P, Lebduska P, Dráberová L, Símová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P. Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):1001–13. PMID: 15477348; PMCID: PMC2211846.; Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W. Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):991–1000. PMID: 15477350; PMCID: PMC2211849.

Metabolites



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name
Q12701 ksg1 Serine/threonine-protein kinase ksg1