Abacavir metabolism

Yuen GJ, Weller S, Pakes GE. A review of the pharmacokinetics of abacavir. Clin Pharmacokinet. 2008;47(6):351–71. doi: 10.2165/00003088-200847060-00001. PMID: 18479171.

Metabolites

Abacavir

Formula: C14H18N6O (286.1542018)

CAS ID: 136470-78-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.1 alcohol dehydrogenase alcohol:NAD+ oxidoreductase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase S-(hydroxymethyl)glutathione:NAD+ oxidoreductase


Proteins

Protein ID name full name
P32771 SFA1 S-(hydroxymethyl)glutathione dehydrogenase