G alpha (12/13) signalling events

Suzuki N, Hajicek N, Kozasa T. Regulation and physiological functions of G12/13-mediated signaling pathways. Neurosignals. 2009;17(1):55–70. PMID: 19212140; PMCID: PMC2836950.; Worzfeld T, Wettschureck N, Offermanns S. G(12)/G(13)-mediated signalling in mammalian physiology and disease. Trends Pharmacol Sci. 2008 Nov;29(11):582–9. doi: 10.1016/j.tips.2008.08.002. PMID: 18814923.; COUGHLIN SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. Journal of Thrombosis and Haemostasis. 2005 Aug;3(8):1800–14. doi: 10.1111/j.1538-7836.2005.01377.x.; Sugimoto N, Takuwa N, Okamoto H, Sakurada S, Takuwa Y. Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G12/13-Rho and Gi Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform. Molecular and Cellular Biology. 2003 Mar 01;23(5):1534–45. doi: 10.1128/mcb.23.5.1534-1545.2003.; Buhl AM, Johnson NL, Dhanasekaran N, Johnson GL. G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem. 1995 Oct 20;270(42):24631–4. doi: 10.1074/jbc.270.42.24631. PMID: 7559569.

Metabolites

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name