Translesion synthesis by POLK

Yoon J, Roy Choudhury J, Park J, Prakash S, Prakash L. A Role for DNA Polymerase ? in Promoting Replication through Oxidative DNA Lesion, Thymine Glycol, in Human Cells. Journal of Biological Chemistry. 2014 May;289(19):13177–85. doi: 10.1074/jbc.m114.556977.; Christov PP, Yamanaka K, Choi J, Takata K, Wood RD, Guengerich FP, Lloyd RS, Rizzo CJ. Replication of the 2,6-Diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine (MeFapy-dGuo) Adduct by Eukaryotic DNA Polymerases. Chem. Res. Toxicol. 2012 Jul 06;25(8):1652–61. doi: 10.1021/tx300113e.; Lior-Hoffmann L, Wang L, Wang S, Geacintov NE, Broyde S, Zhang Y. Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase ? elucidates error-free bypass of a bulky DNA lesion. Nucleic Acids Res. 2012 Oct;40(18):9193–205. PMID: 22772988; PMCID: PMC3467051.; Yoon JH, Bhatia G, Prakash S, Prakash L. Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14116–21. PMID: 20660785; PMCID: PMC2922520.; Vasquez-Del Carpio R, Silverstein TD, Lone S, Swan MK, Choudhury JR, Johnson RE, Prakash S, Prakash L, Aggarwal AK. Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion. PLoS One. 2009 Jun 02;4(6):e5766. PMID: 19492058; PMCID: PMC2686167.; Ohashi E, Hanafusa T, Kamei K, Song I, Tomida J, Hashimoto H, Vaziri C, Ohmori H. Identification of a novel REV1-interacting motif necessary for DNA polymerase ? function. Genes to Cells. 2009 Jan 19;14(2):101–11. doi: 10.1111/j.1365-2443.2008.01255.x.; Avkin S, Goldsmith M, Velasco-Miguel S, Geacintov N, Friedberg EC, Livneh Z. Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa. J Biol Chem. 2004 Dec 17;279(51):53298–305. doi: 10.1074/jbc.m409155200. PMID: 15475561.; Haracska L, Prakash L, Prakash S. Role of human DNA polymerase kappa as an extender in translesion synthesis. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16000–5. PMID: 12444249; PMCID: PMC138554.; Fischhaber PL, Gerlach VL, Feaver WJ, Hatahet Z, Wallace SS, Friedberg EC. Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides. J Biol Chem. 2002 Oct 04;277(40):37604–11. doi: 10.1074/jbc.m206027200. PMID: 12145297.; Haracska L, Unk I, Johnson RE, Phillips BB, Hurwitz J, Prakash L, Prakash S. Stimulation of DNA Synthesis Activity of Human DNA Polymerase ? by PCNA. Molecular and Cellular Biology. 2002 Feb 01;22(3):784–91. doi: 10.1128/mcb.22.3.784-791.2002.; Ohashi E, Bebenek K, Matsuda T, Feaver WJ, Gerlach VL, Friedberg EC, Ohmori H, Kunkel TA. Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. J Biol Chem. 2000 Dec 15;275(50):39678–84. doi: 10.1074/jbc.m005309200. PMID: 11006276.; Zhang Y, Yuan F, Wu X, Wang M, Rechkoblit O, Taylor JS, Geacintov NE, Wang Z. Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro. Nucleic Acids Res. 2000 Nov 01;28(21):4138–46. PMID: 11058110; PMCID: PMC113145.

Metabolites



Enzyme

EC Number name full name note
2.7.7.-
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)


Proteins

Protein ID name full name