Separation of Sister Chromatids

Waizenegger I, Giménez-Abián JF, Wernic D, Peters JM. Regulation of human separase by securin binding and autocleavage. Curr Biol. 2002 Aug 20;12(16):1368–78. doi: 10.1016/s0960-9822(02)01073-4. PMID: 12194817.; Hagting A, Den Elzen N, Vodermaier HC, Waizenegger IC, Peters JM, Pines J. Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol. 2002 Jun 24;157(7):1125–37. PMID: 12070128; PMCID: PMC2173548.; Hauf S, Waizenegger IC, Peters JM. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science. 2001 Aug 17;293(5533):1320–3. doi: 10.1126/science.1061376. PMID: 11509732.; Waizenegger IC, Hauf S, Meinke A, Peters JM. Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Cell. 2000 Oct 27;103(3):399–410. doi: 10.1016/s0092-8674(00)00132-x. PMID: 11081627.; Zou H, McGarry TJ, Bernal T, Kirschner MW. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science. 1999 Jul 16;285(5426):418–22. doi: 10.1126/science.285.5426.418. PMID: 10411507.

Metabolites



Enzyme

EC Number name full name note
2.3.2.-
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.4.22.49 separase
3.6.4.12 DNA helicase


Proteins

Protein ID name full name