Viral mRNA Translation

Goodman AG, Smith JA, Balachandran S, Perwitasari O, Proll SC, Thomas MJ, Korth MJ, Barber GN, Schiff LA, Katze MG. The Cellular Protein P58 IPK Regulates Influenza Virus mRNA Translation and Replication through a PKR-Mediated Mechanism. J Virol. 2007 Mar;81(5):2221–30. doi: 10.1128/jvi.02151-06.; Kash JC, Goodman AG, Korth MJ, Katze MG. Hijacking of the host-cell response and translational control during influenza virus infection. Virus Res. 2006 Jul;119(1):111–20. doi: 10.1016/j.virusres.2005.10.013. PMID: 16630668.; Burgui I, Aragón T, Ortín J, Nieto A. PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes. J Gen Virol. 2003 Dec;84(Pt 12):3263–74. doi: 10.1099/vir.0.19487-0. PMID: 14645908.; Kash JC, Cunningham DM, Smit MW, Park Y, Fritz D, Wilusz J, Katze MG. Selective Translation of Eukaryotic mRNAs: Functional Molecular Analysis of GRSF-1, a Positive Regulator of Influenza Virus Protein Synthesis. J Virol. 2002 Oct 15;76(20):10417–26. doi: 10.1128/jvi.76.20.10417-10426.2002.; Salvatore M, Basler CF, Parisien J, Horvath CM, Bourmakina S, Zheng H, Muster T, Palese P, Garci´a-Sastre A. Effects of Influenza A Virus NS1 Protein on Protein Expression: the NS1 Protein Enhances Translation and Is Not Required for Shutoff of Host Protein Synthesis. J Virol. 2002 Feb;76(3):1206–12. doi: 10.1128/jvi.76.3.1206-1212.2002.; Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O'Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW. A novel influenza A virus mitochondrial protein that induces cell death. Nat Med. 2001 Dec;7(12):1306–12. doi: 10.1038/nm1201-1306. PMID: 11726970.; Park YW, Wilusz J, Katze MG. Regulation of eukaryotic protein synthesis: Selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1. Proc. Natl. Acad. Sci. U.S.A. 1999 Jun 08;96(12):6694–9. doi: 10.1073/pnas.96.12.6694.; Park YW, Katze MG. Translational control by influenza virus. Identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translation. J Biol Chem. 1995 Nov 24;270(47):28433–9. doi: 10.1074/jbc.270.47.28433. PMID: 7499349.; Garfinkel MS, Katze MG. Translational control by influenza virus. Selective and cap-dependent translation of viral mRNAs in infected cells. Journal of Biological Chemistry. 1992 May;267(13):9383–90. doi: 10.1016/s0021-9258(19)50435-5.; Katze MG, DeCorato D, Krug RM. Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirus. J Virol. 1986 Dec;60(3):1027–39. doi: 10.1128/jvi.60.3.1027-1039.1986.

Metabolites



Enzyme

EC Number name full name note
3.1.-.-
2.7.7.48 RNA-directed RNA polymerase nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
3.2.1.18 exo-alpha-sialidase acetylneuraminyl hydrolase
4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase


Proteins

Protein ID name full name