SMAC (DIABLO) binds to IAPs

Burke SP, Smith JB. Monomerization of Cytosolic Mature Smac Attenuates Interaction with IAPs and Potentiation of Caspase Activation. PLoS ONE. 2010 Oct 01;5(10):e13094. doi: 10.1371/journal.pone.0013094.; Abhari BA, Davoodi J. A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases. J Mol Biol. 2008 Sep 05;381(3):645–54. doi: 10.1016/j.jmb.2008.05.082. PMID: 18619610.; Paulsen M, Ussat S, Jakob M, Scherer G, Lepenies I, Schütze S, Kabelitz D, Adam-Klages S. Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes. Eur J Immunol. 2008 Jul;38(7):1979–87. doi: 10.1002/eji.200838211. PMID: 18521960.; Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nature Reviews Molecular Cell Biology. 2002 Jun;3(6):401–10. doi: 10.1038/nrm830.; Wu G, Chai J, Suber TL, Wu JW, Du C, Wang X, Shi Y. Structural basis of IAP recognition by Smac/DIABLO. Nature. 2000 Dec;408(6815):1008–12. doi: 10.1038/35050012. PMID: 11140638.; Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 2000 Dec;408(6815):1004–8. doi: 10.1038/35050006. PMID: 11140637.; Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 2000 Aug 24;406(6798):855–62. doi: 10.1038/35022514. PMID: 10972280.; Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000 Jul 07;102(1):33–42. doi: 10.1016/s0092-8674(00)00008-8. PMID: 10929711.; Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997 Jul 17;388(6639):300–4. doi: 10.1038/40901. PMID: 9230442.

Metabolites



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)


Proteins

Protein ID name full name