GRB2:SOS provides linkage to MAPK signaling for Integrins

Arold ST, Hoellerer MK, Noble ME. The structural basis of localization and signaling by the focal adhesion targeting domain. Structure. 2002 Mar;10(3):319–27. doi: 10.1016/s0969-2126(02)00717-7. PMID: 12005431.; Schlaepfer DD, Jones KC, Hunter T. Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events. Molecular and Cellular Biology. 1998 May 01;18(5):2571–85. doi: 10.1128/mcb.18.5.2571.; Schlaepfer DD, Hanks SK, Hunter T, van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 1994 Dec;372(6508):786–91. doi: 10.1038/372786a0. PMID: 7997267.

Metabolites



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)


Proteins

Protein ID name full name