Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Bhuvanagiri M, Schlitter AM, Hentze MW, Kulozik AE. NMD: RNA biology meets human genetic medicine. Biochem J. 2010 Sep 15;430(3):365–77. doi: 10.1042/bj20100699. PMID: 20795950.; Nicholson P, Yepiskoposyan H, Metze S, Zamudio Orozco R, Kleinschmidt N, Mühlemann O. Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cellular and Molecular Life Sciences. 2009 Oct 27;67(5):677–700. doi: 10.1007/s00018-009-0177-1.; Rebbapragada I, Lykke-Andersen J. Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol. 2009 Jun;21(3):394–402. doi: 10.1016/j.ceb.2009.02.007. PMID: 19359157.; Eberle AB, Stalder L, Mathys H, Orozco RZ, Mühlemann O. Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3' Untranslated Region. PLoS Biol. 2008 Apr 29;6(4):e92. doi: 10.1371/journal.pbio.0060092.; Singh G, Rebbapragada I, Lykke-Andersen J. A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay. PLoS Biol. 2008 Apr 29;6(4):e111. doi: 10.1371/journal.pbio.0060111.; Ivanov PV, Gehring NH, Kunz JB, Hentze MW, Kulozik AE. Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J. 2008 Mar 05;27(5):736–47. PMID: 18256688; PMCID: PMC2265754.; Isken O, Maquat LE. Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev. 2007 Aug 01;21(15):1833–56. doi: 10.1101/gad.1566807. PMID: 17671086.; Chang YF, Imam JS, Wilkinson MF. The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem. 2007;76():51–74. doi: 10.1146/annurev.biochem.76.050106.093909. PMID: 17352659.; Behm-Ansmant I, Kashima I, Rehwinkel J, Saulière J, Wittkopp N, Izaurralde E. mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett. 2007 Jun 19;581(15):2845–53. doi: 10.1016/j.febslet.2007.05.027. PMID: 17531985.

Metabolites



Enzyme

EC Number name full name note
3.6.4.12 DNA helicase
3.6.4.13 RNA helicase


Proteins

Protein ID name full name