Aflatoxin activation and detoxification

Hamid AS, Tesfamariam IG, Zhang Y, Zhang ZG. Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention. Oncol Lett. 2013 Apr;5(4):1087–92. PMID: 23599745; PMCID: PMC3629261.; Wu Q, Jezkova A, Yuan Z, Pavlikova L, Dohnal V, Kuca K. Biological degradation of aflatoxins. Drug Metab Rev. 2009;41(1):1–7. doi: 10.1080/03602530802563850. PMID: 19514968.; Wild CP, Turner PC. The toxicology of aflatoxins as a basis for public health decisions. Mutagenesis. 2002 Nov;17(6):471–81. doi: 10.1093/mutage/17.6.471. PMID: 12435844.; Guengerich FP, Johnson WW, Shimada T, Ueng Y, Yamazaki H, Langouët S. Activation and detoxication of aflatoxin B1. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1998 Jun;402(1-2):121–8. doi: 10.1016/s0027-5107(97)00289-3.

Metabolites

Aflatoxin B1

Formula: C17H12O6 (312.06338519999997)

CAS ID: 1162-65-8

Aflatoxin M1

Formula: C17H12O7 (328.05830019999996)

CAS ID: 6795-23-9

Aflatoxin Q1

Formula: C17H12O7 (328.05830019999996)

CAS ID: 52819-96-2

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)


Proteins

Protein ID name full name