RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Herglotz J, Kuvardina ON, Kolodziej S, Kumar A, Hussong H, Grez M, Lausen J. Histone arginine methylation keeps RUNX1 target genes in an intermediate state. Oncogene. 2013 May 16;32(20):2565–75. doi: 10.1038/onc.2012.274. PMID: 22777353.; Bluteau D, Gilles L, Hilpert M, Antony-Debré I, James C, Debili N, Camara-Clayette V, Wagner-Ballon O, Cordette-Lagarde V, Robert T, Ripoche H, Gonin P, Swierczek S, Prchal J, Vainchenker W, Favier R, Raslova H. Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia. Blood. 2011 Dec 08;118(24):6310–20. doi: 10.1182/blood-2010-12-325555. PMID: 21725049.; Jalagadugula G, Mao G, Kaur G, Dhanasekaran DN, Rao AK. Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1. Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):921–7. PMID: 21252065; PMCID: PMC3066073.; ANEJA K, JALAGADUGULA G, MAO G, SINGH A, RAO AK. Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of. Journal of Thrombosis and Haemostasis. 2011 Feb;9(2):383–91. doi: 10.1111/j.1538-7836.2010.04154.x.; Jalagadugula G, Mao G, Kaur G, Goldfinger LE, Dhanasekaran DN, Rao AK. Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency. Blood. 2010 Dec 23;116(26):6037–45. PMID: 20876458; PMCID: PMC3031389.; Wang W, Schwemmers S, Hexner EO, Pahl HL. AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. Blood. 2010 Jul 15;116(2):254–66. PMID: 20339092; PMCID: PMC2910609.; Ben-Ami O, Pencovich N, Lotem J, Levanon D, Groner Y. A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis. Proc Natl Acad Sci U S A. 2009 Jan 06;106(1):238–43. PMID: 19114653; PMCID: PMC2612036.; Bonnefoy A, Hoylaerts MF. Thrombospondin-1 in von Willebrand factor function. Curr Drug Targets. 2008 Oct;9(10):822–32. doi: 10.2174/138945008785909329. PMID: 18855616.; Zhao X, Jankovic V, Gural A, Huang G, Pardanani A, Menendez S, Zhang J, Dunne R, Xiao A, Erdjument-Bromage H, Allis CD, Tempst P, Nimer SD. Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev. 2008 Mar 01;22(5):640–53. PMID: 18316480; PMCID: PMC2259033.; Xu G, Kanezaki R, Toki T, Watanabe S, Takahashi Y, Terui K, Kitabayashi I, Ito E. Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome. Leukemia. 2006 Jun;20(6):1002–8. doi: 10.1038/sj.leu.2404223. PMID: 16628190.; Elagib KE, Racke FK, Mogass M, Khetawat R, Delehanty LL, Goldfarb AN. RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Blood. 2003 Jun 01;101(11):4333–41. doi: 10.1182/blood-2002-09-2708. PMID: 12576332.; Jilma-Stohlawetz P, Homoncik M, Jilma B, Knechtelsdorfer M, Unger P, Mannhalter C, Santoso S, Panzer S. Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates. Br J Haematol. 2003 Feb;120(4):652–5. doi: 10.1046/j.1365-2141.2003.04083.x. PMID: 12588352.; Cauwenberghs N, Vanhoorelbeke K, Vauterin S, Deckmyn H. Structural determinants within platelet glycoprotein Ibalpha involved in its binding to von Willebrand factor. Platelets. 2000 Nov;11(7):373–8. doi: 10.1080/09537100020019157. PMID: 11132103.; Block KL, Poncz M. Platelet glycoprotein IIb gene expression as a model of megakaryocyte-specific expression. Stem Cells. 1995 Mar;13(2):135–45. doi: 10.1002/stem.5530130205. PMID: 7787779.; Debili N, Kieffer N, Nakazawa M, Guichard J, Titeux M, Cramer E, Breton- Gorius J, Vainchenker W. Expression of platelet glycoprotein Ib by cultured human megakaryocytes: ultrastructural localization and biosynthesis. 1990 Jul 15;76(2):368–76. doi: 10.1182/blood.v76.2.368.bloodjournal762368.