Cargo concentration in the ER

Malhotra V, Erlmann P, Nogueira C. Procollagen export from the endoplasmic reticulum. Biochem Soc Trans. 2015 Feb;43(1):104–7. doi: 10.1042/bst20140286. PMID: 25619253.; Lord C, Ferro-Novick S, Miller EA. The Highly Conserved COPII Coat Complex Sorts Cargo from the Endoplasmic Reticulum and Targets It to the Golgi. Cold Spring Harbor Perspectives in Biology. 2013 Feb 01;5(2):a013367. doi: 10.1101/cshperspect.a013367.; Szul T, Sztul E. COPII and COPI traffic at the ER-Golgi interface. Physiology (Bethesda). 2011 Oct;26(5):348–64. doi: 10.1152/physiol.00017.2011. PMID: 22013193.; Malhotra V, Erlmann P. Protein export at the ER: loading big collagens into COPII carriers. EMBO J. 2011 Aug 31;30(17):3475–80. PMID: 21878990; PMCID: PMC3181478.; Dancourt J, Barlowe C. Protein sorting receptors in the early secretory pathway. Annu Rev Biochem. 2010;79():777–802. doi: 10.1146/annurev-biochem-061608-091319. PMID: 20533886.; Mancias JD, Goldberg J. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. EMBO J. 2008 Nov 05;27(21):2918–28. PMID: 18843296; PMCID: PMC2580787.; Mossessova E, Bickford LC, Goldberg J. SNARE selectivity of the COPII coat. Cell. 2003 Aug 22;114(4):483–95. doi: 10.1016/s0092-8674(03)00608-1. PMID: 12941276.; Miller EA, Beilharz TH, Malkus PN, Lee MC, Hamamoto S, Orci L, Schekman R. Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell. 2003 Aug 22;114(4):497–509. doi: 10.1016/s0092-8674(03)00609-3. PMID: 12941277.; Kanapin A, Batalov S, Davis MJ, Gough J, Grimmond S, Kawaji H, Magrane M, Matsuda H, Schönbach C, Teasdale RD, Yuan Z; RIKEN GER Group; GSL Members. Mouse proteome analysis. Genome Res. 2003 Jun;13(6B):1335–44. PMID: 12819131; PMCID: PMC403658.; Miller E, Antonny B, Hamamoto S, Schekman R. Cargo selection into COPII vesicles is driven by the Sec24p subunit. EMBO J. 2002 Nov 15;21(22):6105–13. PMID: 12426382; PMCID: PMC137197.

Metabolites

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2



Enzyme

EC Number name full name note
3.4.18.1 cathepsin X
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name