Lysosomal oligosaccharide catabolism

Harada Y, Masahara-Negishi Y, Suzuki T. Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells. Glycobiology. 2015 Nov;25(11):1196–205. doi: 10.1093/glycob/cwv055. PMID: 26206502.; Winchester B. Lysosomal metabolism of glycoproteins. Glycobiology. 2005 Jun;15(6):1R–15R. doi: 10.1093/glycob/cwi041. PMID: 15647514.; Aronson NN, Kuranda MJ. Lysosomal degradation of Asn-linked glycoproteins. FASEB J. 1989 Dec;3(14):2615–22. doi: 10.1096/fasebj.3.14.2531691. PMID: 2531691.

Metabolites

D-Mannose

Formula: C6H12O6 (180.0633852)

CAS ID: 3458-28-4

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Succinate

Formula: C4H6O4 (118.0266076)

CAS ID: 110-15-6

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

beta-1,4-Mannosyl-N-acetylglucosamine

Formula: C14H25NO11 (383.14275399999997)

CAS ID: 856224-94-7

Man5GlcNAc-I

Formula: C38H65NO31 (1031.354038)

CAS ID:



Enzyme

EC Number name full name note
3.2.1.24 alpha-mannosidase alpha-D-mannoside mannohydrolase


Proteins

Protein ID name full name