ERBB2 Regulates Cell Motility

Zaoui K, Benseddik K, Daou P, Salaün D, Badache A. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18517–22. PMID: 20937854; PMCID: PMC2972954.; Zaoui K, Honoré S, Isnardon D, Braguer D, Badache A. Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. J Cell Biol. 2008 Nov 03;183(3):401–8. PMID: 18955552; PMCID: PMC2575782.; Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ. Memo Is Homologous to Nonheme Iron Dioxygenases and Binds an ErbB2-derived Phosphopeptide in Its Vestigial Active Site. Journal of Biological Chemistry. 2008 Feb;283(5):2734–40. doi: 10.1074/jbc.m703523200.; Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A. Memo mediates ErbB2-driven cell motility. Nat Cell Biol. 2004 Jun;6(6):515–22. doi: 10.1038/ncb1134. PMID: 15156151.

Metabolites

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2



Enzyme

EC Number name full name note
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name