Wax and plasmalogen biosynthesis

Cheng JB, Russell DW. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. J Biol Chem. 2004 Sep 03;279(36):37789–97. PMID: 15220348; PMCID: PMC2757098.; Nagan N, Zoeller RA. Plasmalogens: biosynthesis and functions. Prog Lipid Res. 2001 May;40(3):199–229. doi: 10.1016/s0163-7827(01)00003-0. PMID: 11275267.; de Vet ECJM, Ijlst L, Oostheim W, Dekker C, Moser HW, van den Bosch H, Wanders RJA. Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities. Journal of Lipid Research. 1999 Nov;40(11):1998–2003. doi: 10.1016/s0022-2275(20)32423-8.

Metabolites

1-Hexadecanol

Formula: C16H34O (242.26095139999998)

CAS ID: 36653-82-4

Formate

Formula: CH2O2 (46.0054792)

CAS ID: 64-18-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Palmityl palmitate

Formula: C32H64O2 (480.4906044)

CAS ID: 540-10-3

Retinol

Formula: C20H30O (286.229653)

CAS ID: 68-26-8

Retinyl palmitate

Formula: C36H60O2 (524.459306)

CAS ID: 79-81-2

Arachidyl alcohol

Formula: C20H42O (298.3235482)

CAS ID: 629-96-9

1-hexadecyl-glycero-3-phosphate

Formula: C19H41O6P (396.26406160000005)

CAS ID:

hexadecanoate

Formula: C16H31O2 (255.2323926)

CAS ID: 143-20-4

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.101 acylglycerone-phosphate reductase 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase
1.2.1.84 alcohol-forming fatty acyl-CoA reductase long-chain acyl-CoA:NADPH reductase
2.3.1.42 glycerone-phosphate O-acyltransferase acyl-CoA:glycerone-phosphate O-acyltransferase
2.5.1.26 alkylglycerone-phosphate synthase 1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase


Proteins

Protein ID name full name