Mineralocorticoid biosynthesis

Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.

Metabolites

11-Deoxycorticosterone

Formula: C21H30O3 (330.21948299999997)

CAS ID: 64-85-7

18-Hydroxycorticosterone

Formula: C21H30O5 (362.209313)

CAS ID: 561-65-9

Aldosterone

Formula: C21H28O5 (360.1936638)

CAS ID: 52-39-1

Corticosterone

Formula: C21H30O4 (346.214398)

CAS ID: 50-22-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

Progesterone

Formula: C21H30O2 (314.224568)

CAS ID: 57-83-0

pregn-5-ene-3,20-dione

Formula: C21H30O2 (314.224568)

CAS ID: 1236-09-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase 3beta-hydroxy-DELTA5-steroid:NAD+ 3-oxidoreductase
1.14.14.16 steroid 21-monooxygenase steroid,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)
1.14.15.4 steroid 11beta-monooxygenase steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
5.3.3.1 steroid DELTA-isomerase 3-oxosteroid DELTA5-DELTA4-isomerase


Proteins

Protein ID name full name