Positive epigenetic regulation of rRNA expression

Grummt I, Längst G. Epigenetic control of RNA polymerase I transcription in mammalian cells. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2013 Mar;1829(3-4):393–404. doi: 10.1016/j.bbagrm.2012.10.004.; Hannan KM, Sanij E, Rothblum LI, Hannan RD, Pearson RB. Dysregulation of RNA polymerase I transcription during disease. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2013 Mar;1829(3-4):342–60. doi: 10.1016/j.bbagrm.2012.10.014.; Goodfellow SJ, Zomerdijk JC. Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. Subcell Biochem. 2013;61():211–36. PMID: 23150253; PMCID: PMC3855190.; McStay B, Grummt I. The epigenetics of rRNA genes: from molecular to chromosome biology. Annu Rev Cell Dev Biol. 2008;24():131–57. doi: 10.1146/annurev.cellbio.24.110707.175259. PMID: 18616426.; Percipalle P, Farrants AK. Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1. Curr Opin Cell Biol. 2006 Jun;18(3):267–74. doi: 10.1016/j.ceb.2006.03.001. PMID: 16574391.

Metabolites



Enzyme

EC Number name full name note
2.3.1.-
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.1.57 diamine N-acetyltransferase acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
2.7.7.6 DNA-directed RNA polymerase nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
3.6.4.13 RNA helicase


Proteins

Protein ID name full name