Acyl chain remodeling of CL

Zachman DK, Chicco AJ, McCune SA, Murphy RC, Moore RL, Sparagna GC. The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart. Journal of Lipid Research. 2010 Mar;51(3):525–34. doi: 10.1194/jlr.m000646.; Taylor WA, Hatch GM. Identification of the Human Mitochondrial Linoleoyl-coenzyme A Monolysocardiolipin Acyltransferase (MLCL AT-1). Journal of Biological Chemistry. 2009 Oct;284(44):30360–71. doi: 10.1074/jbc.m109.048322.; Zhao Y, Chen Y, Li S, Konrad RJ, Cao G. The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. Journal of Lipid Research. 2009 May;50(5):945–56. doi: 10.1194/jlr.m800567-jlr200.; Malhotra A, Xu Y, Ren M, Schlame M. Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2009 Apr;1791(4):314–20. doi: 10.1016/j.bbalip.2009.01.004.; Cao J, Liu Y, Lockwood J, Burn P, Shi Y. A Novel Cardiolipin-remodeling Pathway Revealed by a Gene Encoding an Endoplasmic Reticulum-associated Acyl-CoA:Lysocardiolipin Acyltransferase (ALCAT1) in Mouse. Journal of Biological Chemistry. 2004 Jul;279(30):31727–34. doi: 10.1074/jbc.m402930200.; Xu Y, Kelley RI, Blanck TJJ, Schlame M. Remodeling of Cardiolipin by Phospholipid Transacylation. Journal of Biological Chemistry. 2003 Dec;278(51):51380–5. doi: 10.1074/jbc.m307382200.; Buckland AG, Kinkaid AR, Wilton DC. Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2. Biochim Biophys Acta. 1998 Feb 05;1390(1):65–72. doi: 10.1016/s0005-2760(97)00170-7. PMID: 9487141.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5



Enzyme

EC Number name full name note
2.3.1.-
1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
2.3.1.155 acetyl-CoA C-myristoyltransferase myristoyl-CoA:acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase acyl-CoA:acetyl-CoA C-acyltransferase
2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase
4.2.1.17 enoyl-CoA hydratase (3S)-3-hydroxyacyl-CoA hydro-lyase


Proteins

Protein ID name full name