Biosynthesis of A2E, implicated in retinal degradation

Sparrow JR, Gregory-Roberts E, Yamamoto K, Blonska A, Ghosh SK, Ueda K, Zhou J. The bisretinoids of retinal pigment epithelium. Progress in Retinal and Eye Research. 2012 Mar;31(2):121–35. doi: 10.1016/j.preteyeres.2011.12.001.; Sparrow JR, Wu Y, Kim CY, Zhou J. Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. Journal of Lipid Research. 2010 Feb;51(2):247–61. doi: 10.1194/jlr.r000687.; Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda). 2010 Feb;25(1):8–15. PMID: 20134024; PMCID: PMC2839896.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Retinal

Formula: C20H28O (284.2140038)

CAS ID: 116-31-4

N-Retinylidene-N-retinylethanolamine

Formula: C42H58NO (592.4518158)

CAS ID: 147427-87-0



Enzyme

EC Number name full name note
3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D N-acetylphosphatidylethanolamine phosphatidohydrolase


Proteins

Protein ID name full name