Threonine catabolism

Edgar AJ. The human L-threonine 3-dehydrogenase gene is an expressed pseudogene. BMC Genomic Data. 2002 Oct 02;3(1):18. doi: 10.1186/1471-2156-3-18.; Darling PB, Grunow J, Rafii M, Brookes S, Ball RO, Pencharz PB. Threonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. American Journal of Physiology-Endocrinology and Metabolism. 2000 May 01;278(5):E877–84. doi: 10.1152/ajpendo.2000.278.5.e877.; Tressel T, Thompson R, Zieske LR, Menendez MI, Davis L. Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production. Journal of Biological Chemistry. 1986 Dec;261(35):16428–37. doi: 10.1016/s0021-9258(18)66584-6.; Bird MI, Nunn PB. Metabolic homoeostasis of L-threonine in the normally-fed rat. Importance of liver threonine dehydrogenase activity. Biochem J. 1983 Sep 15;214(3):687–94. PMID: 6414460; PMCID: PMC1152304.; Dale RA. Catabolism of threonine in mammals by coupling of l-threonine 3-dehydrogenase with 2-amino-3-oxobutyrate-CoA ligase. Biochimica et Biophysica Acta (BBA) - General Subjects. 1978 Dec;544(3):496–503. doi: 10.1016/0304-4165(78)90324-0.

Metabolites

2-Iminobutanoate

Formula: C4H7NO2 (101.0476762)

CAS ID: 4250-86-6

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxobutanoate

Formula: C4H5O3 (101.02386800000001)

CAS ID:



Enzyme

EC Number name full name note
3.5.99.10 2-iminobutanoate/2-iminopropanoate deaminase 2-iminobutanoate aminohydrolase
4.3.1.17 L-serine ammonia-lyase L-serine ammonia-lyase (pyruvate-forming)
4.3.1.19 threonine ammonia-lyase L-threonine ammonia-lyase (2-oxobutanoate-forming)
5.1.1.3 glutamate racemase glutamate racemase


Proteins

Protein ID name full name