NOSIP mediated eNOS trafficking

Oess S, Icking A, Fulton D, Govers R, Müller-Esterl W. Subcellular targeting and trafficking of nitric oxide synthases. Biochem J. 2006 Jun 15;396(3):401–9. PMID: 16722822; PMCID: PMC1482820.; Icking A, Matt S, Opitz N, Wiesenthal A, Müller-Esterl W, Schilling K. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J Cell Sci. 2005 Nov 01;118(Pt 21):5059–69. doi: 10.1242/jcs.02620. PMID: 16234328.; Schleicher M, Brundin F, Gross S, Müller-Esterl W, Oess S. Cell Cycle-Regulated Inactivation of Endothelial NO Synthase through NOSIP-Dependent Targeting to the Cytoskeleton. Molecular and Cellular Biology. 2005 Sep 01;25(18):8251–8. doi: 10.1128/mcb.25.18.8251-8258.2005.; Kone BC, Kuncewicz T, Zhang W, Yu Z. Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. American Journal of Physiology-Renal Physiology. 2003 Aug;285(2):F178–90. doi: 10.1152/ajprenal.00048.2003.; Dedio J, König P, Wohlfart P, Schroeder C, Kummer W, Müller-Esterl W. NOSIP, a novel modulator of endothelial nitric oxide synthase activity. FASEB J. 2001 Jan;15(1):79–89. doi: 10.1096/fj.00-0078com. PMID: 11149895.

Metabolites

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7



Enzyme

EC Number name full name note
1.14.13.39 nitric-oxide synthase (NADPH) L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)


Proteins

Protein ID name full name