Biosynthesis of DPAn-3-derived maresins

Vik A, Dalli J, Hansen TV. Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid. Bioorganic & Medicinal Chemistry Letters. 2017 Jun;27(11):2259–66. doi: 10.1016/j.bmcl.2017.03.079.; Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2015 Apr;1851(4):397–413. doi: 10.1016/j.bbalip.2014.08.006.; Dalli J, Colas RA, Serhan CN. Novel n-3 Immunoresolvents: Structures and Actions. Scientific Reports. 2013 Jun 05;3(1):1940. doi: 10.1038/srep01940.

Metabolites

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.13.11.-
1.13.11.31 arachidonate 12-lipoxygenase arachidonate:oxygen 12-oxidoreductase
1.13.11.33 arachidonate 15-lipoxygenase arachidonate:oxygen 15-oxidoreductase
1.13.11.34 arachidonate 5-lipoxygenase arachidonate:oxygen 5-oxidoreductase


Proteins

Protein ID name full name