mRNA decay by 3' to 5' exoribonuclease

Houseley J, Tollervey D. The many pathways of RNA degradation. Cell. 2009 Feb 20;136(4):763–76. doi: 10.1016/j.cell.2009.01.019. PMID: 19239894.; Garneau NL, Wilusz J, Wilusz CJ. The highways and byways of mRNA decay. Nature Reviews Molecular Cell Biology. 2007 Feb;8(2):113–26. doi: 10.1038/nrm2104.; Moore MJ. From birth to death: the complex lives of eukaryotic mRNAs. Science. 2005 Sep 02;309(5740):1514–8. doi: 10.1126/science.1111443. PMID: 16141059.; Fritz DT, Bergman N, Kilpatrick WJ, Wilusz CJ, Wilusz J. Messenger RNA decay in mammalian cells: the exonuclease perspective. Cell Biochem Biophys. 2004;41(2):265–78. doi: 10.1385/cbb:41:2:265. PMID: 15475613.; Parker R, Song H. The enzymes and control of eukaryotic mRNA turnover. Nature Structural & Molecular Biology. 2004 Feb;11(2):121–7. doi: 10.1038/nsmb724.; Wilusz CJ, Wormington M, Peltz SW. The cap-to-tail guide to mRNA turnover. Nature Reviews Molecular Cell Biology. 2001 Apr;2(4):237–46. doi: 10.1038/35067025.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

N7-Methylguanosine

Formula: C11H16N5O5 (298.1151386)

CAS ID: 20244-86-4



Enzyme

EC Number name full name note
3.1.13.-
3.1.3.5 5'-nucleotidase 5'-ribonucleotide phosphohydrolase
3.6.1.59 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase


Proteins

Protein ID name full name