Formation of the Early Elongation Complex
Yamaguchi Y, Inukai N, Narita T, Wada T, Handa H. Evidence that Negative Elongation Factor Represses Transcription Elongation through Binding to a DRB Sensitivity-Inducing Factor/RNA Polymerase II Complex and RNA. Molecular and Cellular Biology. 2002 May 01;22(9):2918–27. doi: 10.1128/mcb.22.9.2918-2927.2002.; Conaway JW, Shilatifard A, Dvir A, Conaway RC. Control of elongation by RNA polymerase II. Trends Biochem Sci. 2000 Aug;25(8):375–80. doi: 10.1016/s0968-0004(00)01615-7. PMID: 10916156.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.7.11.23 | [RNA-polymerase]-subunit kinase | ATP:[DNA-directed RNA polymerase] phosphotransferase | |
| 2.7.7.6 | DNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) | |
| 3.1.3.16 | protein-serine/threonine phosphatase | protein-serine/threonine-phosphate phosphohydrolase | |
| 5.6.2.3 | DNA 5'-3' helicase | DNA 5'-3' helicase (ATP-hydrolysing) | |
| 5.6.2.4 | DNA 3'-5' helicase | DNA 3'-5' helicase (ATP-hydrolysing) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P04050 | RPO21 | DNA-directed RNA polymerase II subunit RPB1 |
| P06242 | KIN28 | Serine/threonine-protein kinase KIN28 |
| P06839 | RAD3 | General transcription and DNA repair factor IIH helicase subunit XPD/RAD3 |
| P08518 | RPB2 | DNA-directed RNA polymerase II subunit RPB2 |
| Q00578 | SSL2 | General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 |
| Q03254 | FCP1 | RNA polymerase II subunit A C-terminal domain phosphatase |