rRNA processing

Yu Y, Meier UT. RNA-guided isomerization of uridine to pseudouridine—pseudouridylation. RNA Biology. 2014 Dec 02;11(12):1483–94. doi: 10.4161/15476286.2014.972855.; Henras AK, Plisson-Chastang C, O'Donohue MF, Chakraborty A, Gleizes PE. An overview of pre-ribosomal RNA processing in eukaryotes. Wiley Interdiscip Rev RNA. 2015 Mar;6(2):225–42. PMID: 25346433; PMCID: PMC4361047.; Boschi-Muller S, Motorin Y. Chemistry enters nucleic acids biology: enzymatic mechanisms of RNA modification. Biochemistry (Mosc). 2013 Dec;78(13):1392–404. doi: 10.1134/s0006297913130026. PMID: 24490730.; Hernandez-Verdun D, Roussel P, Thiry M, Sirri V, Lafontaine DL. The nucleolus: structure/function relationship in RNA metabolism. Wiley Interdiscip Rev RNA. 2010 Nov;1(3):415–31. doi: 10.1002/wrna.39. PMID: 21956940.; Freed EF, Bleichert F, Dutca LM, Baserga SJ. When ribosomes go bad: diseases of ribosome biogenesis. Mol Biosyst. 2010 Mar;6(3):481–93. PMID: 20174677; PMCID: PMC2965583.; Hamma T, Ferré-D'Amaré AR. The Box H/ACA Ribonucleoprotein Complex: Interplay of RNA and Protein Structures in Post-transcriptional RNA Modification. Journal of Biological Chemistry. 2010 Jan;285(2):805–9. doi: 10.1074/jbc.r109.076893.; Henras AK, Dez C, Henry Y. RNA structure and function in C/D and H/ACA s(no)RNPs. Current Opinion in Structural Biology. 2004 Jun;14(3):335–43. doi: 10.1016/j.sbi.2004.05.006.; Stanek D, Koberna K, Pliss A, Malínský J, Masata M, Vecerová J, Risueño MC, Raska I. Non-isotopic mapping of ribosomal RNA synthesis and processing in the nucleolus. Chromosoma. 2001 Dec;110(7):460–70. doi: 10.1007/s00412-001-0172-2. PMID: 11862453.

Metabolites



Enzyme

EC Number name full name note
2.7.1.-
2.1.1.260 rRNA small subunit pseudouridine methyltransferase Nep1 S-adenosyl-L-methionine:18S rRNA (pseudouridine1191-N1)-methyltransferase
2.1.1.309 18S rRNA (guanine1575-N7)-methyltransferase S-adenosyl-L-methionine:18S rRNA (guanine1575-N7)-methyltransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.1.26.5 ribonuclease P
3.6.4.13 RNA helicase


Proteins

Protein ID name full name
P25627 BUD23 18S rRNA (guanine(1575)-N(7))-methyltransferase
P29295 HRR25 Casein kinase I homolog HRR25
P38712 RRP3 ATP-dependent rRNA helicase RRP3
P38719 DBP8 ATP-dependent RNA helicase DBP8
P38786 RPP1 Ribonuclease P/MRP protein subunit RPP1
P40160 RIO2 Serine/threonine-protein kinase RIO2
P40571 RPR2 Ribonuclease P protein subunit RPR2
P45818 ROK1 ATP-dependent RNA helicase ROK1
P47047 MTR4 ATP-dependent RNA helicase DOB1
Q04217 ECM16 Probable ATP-dependent RNA helicase DHR1
Q06287 EMG1 Ribosomal RNA small subunit methyltransferase NEP1
Q07845 GRC3 Polynucleotide 5'-hydroxyl-kinase GRC3
Q08444 NOB1 20S-pre-rRNA D-site endonuclease NOB1
Q12149 RRP6 Exosome complex exonuclease RRP6
Q12196 RIO1 Serine/threonine-protein kinase RIO1