mRNA decay by 5' to 3' exoribonuclease

Ozgur S, Chekulaeva M, Stoecklin G. Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies. Molecular and Cellular Biology. 2010 Sep 01;30(17):4308–23. doi: 10.1128/mcb.00429-10.; Houseley J, Tollervey D. The many pathways of RNA degradation. Cell. 2009 Feb 20;136(4):763–76. doi: 10.1016/j.cell.2009.01.019. PMID: 19239894.; Garneau NL, Wilusz J, Wilusz CJ. The highways and byways of mRNA decay. Nature Reviews Molecular Cell Biology. 2007 Feb;8(2):113–26. doi: 10.1038/nrm2104.; Moore MJ. From birth to death: the complex lives of eukaryotic mRNAs. Science. 2005 Sep 02;309(5740):1514–8. doi: 10.1126/science.1111443. PMID: 16141059.; Fritz DT, Bergman N, Kilpatrick WJ, Wilusz CJ, Wilusz J. Messenger RNA decay in mammalian cells: the exonuclease perspective. Cell Biochem Biophys. 2004;41(2):265–78. doi: 10.1385/cbb:41:2:265. PMID: 15475613.; Parker R, Song H. The enzymes and control of eukaryotic mRNA turnover. Nature Structural & Molecular Biology. 2004 Feb;11(2):121–7. doi: 10.1038/nsmb724.; Wilusz CJ, Wormington M, Peltz SW. The cap-to-tail guide to mRNA turnover. Nature Reviews Molecular Cell Biology. 2001 Apr;2(4):237–46. doi: 10.1038/35067025.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

N7-Methylguanosine

Formula: C11H16N5O5 (298.1151386)

CAS ID: 20244-86-4



Enzyme

EC Number name full name note
3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] N7-methylguanosine-5'-diphosphate phosphohydrolase
3.6.4.13 RNA helicase


Proteins

Protein ID name full name
P39517 DHH1 ATP-dependent RNA helicase DHH1
P53550 DCP2 m7GpppN-mRNA hydrolase