Recruitment of NuMA to mitotic centrosomes

Kisurina-Evgenieva O, Mack G, Du Q, Macara I, Khodjakov A, Compton DA. Multiple mechanisms regulate NuMA dynamics at spindle poles. J Cell Sci. 2004 Dec 15;117(Pt 26):6391–400. doi: 10.1242/jcs.01568. PMID: 15561764.; Wiese C, Wilde A, Moore MS, Adam SA, Merdes A, Zheng Y. Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. Science. 2001 Jan 26;291(5504):653–6. doi: 10.1126/science.1057661. PMID: 11229403.; Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell. 2001 Jan 12;104(1):95–106. doi: 10.1016/s0092-8674(01)00194-5. PMID: 11163243.; Merdes A, Heald R, Samejima K, Earnshaw WC, Cleveland DW. Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. J Cell Biol. 2000 May 15;149(4):851–62. PMID: 10811826; PMCID: PMC2174573.; Merdes A, Cleveland DW. The role of NuMA in the interphase nucleus. J Cell Sci. 1998 Jan;111 ( Pt 1)():71–9. doi: 10.1242/jcs.111.1.71. PMID: 9394013.; Merdes A, Ramyar K, Vechio JD, Cleveland DW. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell. 1996 Nov 01;87(3):447–58. doi: 10.1016/s0092-8674(00)81365-3. PMID: 8898198.; Gaglio T, Saredi A, Bingham JB, Hasbani MJ, Gill SR, Schroer TA, Compton DA. Opposing motor activities are required for the organization of the mammalian mitotic spindle pole. J Cell Biol. 1996 Oct;135(2):399–414. PMID: 8896597; PMCID: PMC2121053.; Gaglio T, Saredi A, Compton DA. NuMA is required for the organization of microtubules into aster-like mitotic arrays. J Cell Biol. 1995 Nov;131(3):693–708. PMID: 7593190; PMCID: PMC2120610.; Tang TK, Tang CJ, Chao YJ, Wu CW. Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various NuMA isoforms. J Cell Sci. 1994 Jun;107 ( Pt 6)():1389–402. doi: 10.1242/jcs.107.6.1389. PMID: 7962183.

Metabolites



Enzyme

EC Number name full name note
3.1.11.-
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.11 cAMP-dependent protein kinase ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)


Proteins

Protein ID name full name