Metabolism of ingested MeSeO2H into MeSeH

Lu J, Berndt C, Holmgren A. Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase. Biochimica et Biophysica Acta (BBA) - General Subjects. 2009 Nov;1790(11):1513–9. doi: 10.1016/j.bbagen.2009.04.013.; Gromer S, Gross JH. Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium. J Biol Chem. 2002 Mar 22;277(12):9701–6. doi: 10.1074/jbc.m109234200. PMID: 11782468.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Methylselenic acid

Formula: CH4O2Se (127.9376494)

CAS ID: 28274-57-9

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

Methaneselenol

Formula: CH3Se (94.93999480000001)

CAS ID: 60343-91-1



Enzyme

EC Number name full name note
1.11.1.2 NADPH peroxidase NADPH:hydrogen-peroxide oxidoreductase
1.8.1.9 thioredoxin-disulfide reductase thioredoxin:NADP+ oxidoreductase


Proteins

Protein ID name full name