Beta-oxidation of pristanoyl-CoA

Wanders RJ, Waterham HR. Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem. 2006;75():295–332. doi: 10.1146/annurev.biochem.74.082803.133329. PMID: 16756494.; Ferdinandusse S, Mulders J, IJlst L, Denis S, Dacremont G, Waterham HR, Wanders RJA. Molecular Cloning and Expression of Human Carnitine Octanoyltransferase: Evidence for Its Role in the Peroxisomal ß-Oxidation of Branched-Chain Fatty Acids. Biochemical and Biophysical Research Communications. 1999 Sep;263(1):213–8. doi: 10.1006/bbrc.1999.1340.; Verhoeven NM, Roe DS, Kok RM, Wanders RJA, Jakobs C, Roe CR. Phytanic acid and pristanic acid are oxidized by sequential peroxisomal and mitochondrial reactions in cultured fibroblasts. Journal of Lipid Research. 1998 Jan;39(1):66–74. doi: 10.1016/s0022-2275(20)34204-8.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

L-Carnitine

Formula: C7H15NO3 (161.105188)

CAS ID: 541-15-1

O-Propanoylcarnitine

Formula: C10H19NO4 (217.1314014)

CAS ID: 20064-19-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

3-hydroxypristanoyl-CoA

Formula: C40H72N7O18P3S (1063.3867202000001)

CAS ID:

Acetyl-L-carnitine

Formula: C9H17NO4 (203.1157522)

CAS ID: 3040-38-8

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.1.n12
1.17.99.3 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating)
1.3.3.6 acyl-CoA oxidase acyl-CoA:oxygen 2-oxidoreductase
2.3.1.137 carnitine O-octanoyltransferase octanoyl-CoA:L-carnitine O-octanoyltransferase
2.3.1.155 acetyl-CoA C-myristoyltransferase myristoyl-CoA:acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase acyl-CoA:acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
2.3.1.7 carnitine O-acetyltransferase acetyl-CoA:carnitine O-acetyltransferase
3.1.2.1 acetyl-CoA hydrolase acetyl-CoA hydrolase
3.1.2.11 acetoacetyl-CoA hydrolase acetoacetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase
3.1.2.27 choloyl-CoA hydrolase choloyl-CoA hydrolase
3.1.2.3 succinyl-CoA hydrolase succinyl-CoA hydrolase
3.1.2.5 hydroxymethylglutaryl-CoA hydrolase (S)-3-hydroxy-3-methylglutaryl-CoA hydrolase
4.2.1.107 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming]
4.2.1.119 enoyl-CoA hydratase 2 (3R)-3-hydroxyacyl-CoA hydro-lyase
5.1.99.4 alpha-methylacyl-CoA racemase 2-Methylacyl-CoA 2-epimerase


Proteins

Protein ID name full name