G1/S-Specific Transcription

Zhu W, Giangrande PH, Nevins JR. E2Fs link the control of G1/S and G2/M transcription. EMBO J. 2004 Nov 24;23(23):4615–26. PMID: 15510213; PMCID: PMC533046.; Reis T, Edgar BA. Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing. Cell. 2004 Apr 16;117(2):253–64. doi: 10.1016/s0092-8674(04)00247-8. PMID: 15084262.; Giangrande PH, Zhu W, Rempel RE, Laakso N, Nevins JR. Combinatorial gene control involving E2F and E Box family members. EMBO J. 2004 Mar 24;23(6):1336–47. PMID: 15014447; PMCID: PMC381409.; Yoshida K, Inoue I. Regulation of Geminin and Cdt1 expression by E2F transcription factors. Oncogene. 2004 May 06;23(21):3802–12. doi: 10.1038/sj.onc.1207488. PMID: 14990995.; Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol. 2002 May;4(5):358–66. doi: 10.1038/ncb785. PMID: 11988738.; Arata Y, Fujita M, Ohtani K, Kijima S, Kato J. Cdk2-dependent and -independent Pathways in E2F-mediated S Phase Induction. Journal of Biological Chemistry. 2000 Mar;275(9):6337–45. doi: 10.1074/jbc.275.9.6337.; Darbinian N, Gallia GL, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K. Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene. 1999 Nov 04;18(46):6398–402. doi: 10.1038/sj.onc.1203011. PMID: 10597240.; Vigo E, Müller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K. CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase. Molecular and Cellular Biology. 1999 Sep 01;19(9):6379–95. doi: 10.1128/mcb.19.9.6379.; Asano M, Wharton RP. E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila. EMBO J. 1999 May 04;18(9):2435–48. PMID: 10228158; PMCID: PMC1171326.; Ohtani K, Tsujimoto A, Ikeda M, Nakamura M. Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. Oncogene. 1998 Oct 08;17(14):1777–85. doi: 10.1038/sj.onc.1202105. PMID: 9778043.; Liu N, Lucibello FC, Engeland K, Müller R. A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F. Oncogene. 1998 Jun 11;16(23):2957–63. doi: 10.1038/sj.onc.1201838. PMID: 9662327.; Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 1998 Mar 31;95(7):3603–8. doi: 10.1073/pnas.95.7.3603.; Wells JM, Illenye S, Magae J, Wu C, Heintz NH. Accumulation of E2F-4·DP-1 DNA Binding Complexes Correlates with Induction of dhfr Gene Expression during the G1 to S Phase Transition. Journal of Biological Chemistry. 1997 Feb;272(7):4483–92. doi: 10.1074/jbc.272.7.4483.; Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR. Expression of the HsOrc1 Gene, a Human ORC1 Homolog, Is Regulated by Cell Proliferation via the E2F Transcription Factor. Molecular and Cellular Biology. 1996 Dec 01;16(12):6977–84. doi: 10.1128/mcb.16.12.6977.; Ohtani K, DeGregori J, Nevins JR. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. U.S.A. 1995 Dec 19;92(26):12146–50. doi: 10.1073/pnas.92.26.12146.; DeGregori J, Kowalik T, Nevins JR. Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G1/S-Regulatory Genes. Molecular and Cellular Biology. 1995 Aug 01;15(8):4215–24. doi: 10.1128/mcb.15.8.4215.; Furukawa Y, Terui Y, Sakoe K, Ohta M, Saito M. The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells. Journal of Biological Chemistry. 1994 Oct;269(42):26249–58. doi: 10.1016/s0021-9258(18)47187-6.; Duronio RJ, O'Farrell PH. Developmental control of a G1-S transcriptional program in Drosophila. Development. 1994 Jun;120(6):1503–15. PMID: 8050359; PMCID: PMC2753441.; Ohtani K, Nevins JR. Functional Properties of a Drosophila Homolog of the E2F1 Gene. Molecular and Cellular Biology. 1994 Mar 01;14(3):1603–12. doi: 10.1128/mcb.14.3.1603-1612.1994.; Dou QP, Zhao S, Levin AH, Wang J, Helin K, Pardee AB. G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. Journal of Biological Chemistry. 1994 Jan;269(2):1306–13. doi: 10.1016/s0021-9258(17)42259-9.

Metabolites



Enzyme

EC Number name full name note
1.17.4.1 ribonucleoside-diphosphate reductase 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
1.5.1.3 dihydrofolate reductase 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
2.1.1.45 thymidylate synthase 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
2.7.1.21 thymidine kinase ATP:thymidine 5'-phosphotransferase
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)


Proteins

Protein ID name full name