Regulated proteolysis of p75NTR

Bronfman FC. Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling? J Neurochem. 2007 Nov;103 Suppl 1():91–100. doi: 10.1111/j.1471-4159.2007.04781.x. PMID: 17986144.; Urra S, Escudero CA, Ramos P, Lisbona F, Allende E, Covarrubias P, Parraguez JI, Zampieri N, Chao MV, Annaert W, Bronfman FC. TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain. J Biol Chem. 2007 Mar 09;282(10):7606–15. doi: 10.1074/jbc.m610458200. PMID: 17215246.

Metabolites

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
3.4.24.86 ADAM 17 endopeptidase


Proteins

Protein ID name full name