WNT ligand biogenesis and trafficking
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E. The way Wnt works: Components and mechanism. Growth Factors. 2012 Dec 21;31(1):1–31. doi: 10.3109/08977194.2012.752737.; Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell. 2012 Dec 21;151(7):1542–56. doi: 10.1016/j.cell.2012.11.024. PMID: 23260141.; Gross JC, Chaudhary V, Bartscherer K, Boutros M. Active Wnt proteins are secreted on exosomes. Nat Cell Biol. 2012 Oct;14(10):1036–45. doi: 10.1038/ncb2574. PMID: 22983114.; Willert K, Nusse R. Wnt Proteins. Cold Spring Harbor Perspectives in Biology. 2012 Sep 01;4(9):a007864. doi: 10.1101/cshperspect.a007864.; Herr P, Hausmann G, Basler K. WNT secretion and signalling in human disease. Trends Mol Med. 2012 Aug;18(8):483–93. doi: 10.1016/j.molmed.2012.06.008. PMID: 22796206.; Janda CY, Waghray D, Levin AM, Thomas C, Garcia KC. Structural basis of Wnt recognition by Frizzled. Science. 2012 Jul 06;337(6090):59–64. PMID: 22653731; PMCID: PMC3577348.; Barrott JJ, Cash GM, Smith AP, Barrow JR, Murtaugh LC. Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc. Natl. Acad. Sci. U.S.A. 2011 Jul 18;108(31):12752–7. doi: 10.1073/pnas.1006437108.; Biechele S, Cox BJ, Rossant J. Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. Dev Biol. 2011 Jul 15;355(2):275–85. doi: 10.1016/j.ydbio.2011.04.029. PMID: 21554866.; Johannes L, Wunder C. The SNXy flavours of endosomal sorting. Nat Cell Biol. 2011 Jul 03;13(8):884–6. doi: 10.1038/ncb2300. PMID: 21725318.; Korkut C, Ataman B, Ramachandran P, Ashley J, Barria R, Gherbesi N, Budnik V. Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. Cell. 2009 Oct 16;139(2):393–404. PMID: 19837038; PMCID: PMC2785045.; Goodman RM, Thombre S, Firtina Z, Gray D, Betts D, Roebuck J, Spana EP, Selva EM. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Development. 2006 Dec;133(24):4901–11. doi: 10.1242/dev.02674. PMID: 17108000.; Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S. Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell. 2006 Dec;11(6):791–801. doi: 10.1016/j.devcel.2006.10.003. PMID: 17141155.; Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell. 2006 May 05;125(3):509–22. doi: 10.1016/j.cell.2006.02.049. PMID: 16678095.; Bartscherer K, Pelte N, Ingelfinger D, Boutros M. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell. 2006 May 05;125(3):523–33. doi: 10.1016/j.cell.2006.04.009. PMID: 16678096.