The retinoid cycle in cones (daylight vision)

von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; Kefalov VJ. Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches. Journal of Biological Chemistry. 2012 Jan;287(3):1635–41. doi: 10.1074/jbc.r111.303008.; Wang J, Kefalov VJ. The Cone-specific visual cycle. Progress in Retinal and Eye Research. 2011 Mar;30(2):115–28. doi: 10.1016/j.preteyeres.2010.11.001.; Wolf G. The visual cycle of the cone photoreceptors of the retina. Nutr Rev. 2004 Jul;62(7 Pt 1):283–6. doi: 10.1111/j.1753-4887.2004.tb00053.x. PMID: 15384919.

Metabolites

11-cis-Retinal

Formula: C20H28O (284.2140038)

CAS ID: 564-87-4

11-cis-Retinol

Formula: C20H30O (286.229653)

CAS ID: 22737-96-8

11-cis-Retinyl palmitate

Formula: C36H60O2 (524.459306)

CAS ID: 51249-33-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Retinal

Formula: C20H28O (284.2140038)

CAS ID: 116-31-4

Retinol

Formula: C20H30O (286.229653)

CAS ID: 68-26-8

hexadecanoate

Formula: C16H31O2 (255.2323926)

CAS ID: 143-20-4

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.300 NADP-retinol dehydrogenase retinol:NADP+ oxidoreductase
2.3.1.20 diacylglycerol O-acyltransferase acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
2.3.1.75 long-chain-alcohol O-fatty-acyltransferase acyl-CoA:long-chain-alcohol O-acyltransferase
2.3.1.76 retinol O-fatty-acyltransferase acyl-CoA:retinol O-acyltransferase


Proteins

Protein ID name full name