Glucuronidation

Wells PG, Mackenzie PI, Roy Chowdhury J, Guillemette C, Gregory PA, Ishii Y, Hansen AJ, Kessler FK, Kim PM, Roy Chowdhury N, Ritter JK. GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE. Drug Metabolism and Disposition. 2004 Mar;32(3):281–90. doi: 10.1124/dmd.32.3.281.; Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000;40():581–616. doi: 10.1146/annurev.pharmtox.40.1.581. PMID: 10836148.

Metabolites

Bilirubin-glucuronoside

Formula: C39H44N4O12 (760.2955584)

CAS ID: 27071-67-6

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Glycitein

Formula: C16H12O5 (284.0684702)

CAS ID: 40957-83-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Mycophenolic acid O-acyl-glucuronide

Formula: C23H28O12 (496.1580688)

CAS ID: 99043-04-6

mycophenolate

Formula: C17H19O6 (319.1181574)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0



Enzyme

EC Number name full name note
1.1.1.22 UDP-glucose 6-dehydrogenase UDP-alpha-D-glucose:NAD+ 6-oxidoreductase
2.4.1.17 glucuronosyltransferase UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
2.7.7.9 UTP-glucose-1-phosphate uridylyltransferase UTP:alpha-D-glucose-1-phosphate uridylyltransferase
3.1.1.93 mycophenolic acid acyl-glucuronide esterase mycophenolic acid O-acyl-glucuronide-ester hydrolase
3.1.2.22 palmitoyl[protein] hydrolase palmitoyl[protein] hydrolase
4.1.1.35 UDP-glucuronate decarboxylase UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)


Proteins

Protein ID name full name