Degradation of the extracellular matrix

Lu P, Takai K, Weaver VM, Werb Z. Extracellular Matrix Degradation and Remodeling in Development and Disease. Cold Spring Harbor Perspectives in Biology. 2011 Sep 14;3(12):a005058. doi: 10.1101/cshperspect.a005058.; Hadler-Olsen E, Fadnes B, Sylte I, Uhlin-Hansen L, Winberg JO. Regulation of matrix metalloproteinase activity in health and disease. FEBS J. 2011 Jan;278(1):28–45. doi: 10.1111/j.1742-4658.2010.07920.x. PMID: 21087458.; Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res. 2006 Feb 15;69(3):562–73. doi: 10.1016/j.cardiores.2005.12.002. PMID: 16405877.; Somerville RP, Oblander SA, Apte SS. Matrix metalloproteinases: old dogs with new tricks. Genome Biology. 2003 May 29;4(6):216. doi: 10.1186/gb-2003-4-6-216.; Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003 May 02;92(8):827–39. doi: 10.1161/01.res.0000070112.80711.3d. PMID: 12730128.; Stöcker W, Bode W. Structural features of a superfamily of zinc-endopeptidases: the metzincins. Current Opinion in Structural Biology. 1995 Jun;5(3):383–90. doi: 10.1016/0959-440x(95)80101-4.; Van Wart HE, Birkedal-Hansen H. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc. Natl. Acad. Sci. U.S.A. 1990 Jul;87(14):5578–82. doi: 10.1073/pnas.87.14.5578.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5



Enzyme

EC Number name full name note
3.4.21.-
3.4.21.20 cathepsin G
3.4.21.37 leukocyte elastase
3.4.21.75 Furin
3.4.22.52 calpain-1
3.4.24.17 stromelysin 1
3.4.24.22 stromelysin 2
3.4.24.23 matrilysin
3.4.24.24 gelatinase A
3.4.24.34 neutrophil collagenase
3.4.24.35 gelatinase B
3.4.24.65 macrophage elastase
3.4.24.7 interstitial collagenase
3.4.24.80 membrane-type matrix metalloproteinase-1
4.2.3.134 5-phosphooxy-L-lysine phospho-lyase (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)


Proteins

Protein ID name full name