sphingolipid biosynthesis
Vallée B, Riezman H. Lip1p: a novel subunit of acyl-CoA ceramide synthase. EMBO J. 2005 Feb 23;24(4):730–41. PMID: 15692566; PMCID: PMC549621.; Kihara A, Igarashi Y. Identification and Characterization of aSaccharomyces cerevisiae Gene, RSB1, Involved in Sphingoid Long-chain Base Release. Journal of Biological Chemistry. 2002 Aug;277(33):30048–54. doi: 10.1074/jbc.m203385200.; Dickson RC, Lester RL. Sphingolipid functions in Saccharomyces cerevisiae. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2002 Jun;1583(1):13–25. doi: 10.1016/s1388-1981(02)00210-x.; Kohlwein SD, Eder S, Oh C, Martin CE, Gable K, Bacikova D, Dunn T. Tsc13p Is Required for Fatty Acid Elongation and Localizes to a Novel Structure at the Nuclear-Vacuolar Interface in Saccharomyces cerevisiae. Molecular and Cellular Biology. 2001 Jan 01;21(1):109–25. doi: 10.1128/mcb.21.1.109-125.2001.
Metabolites
cyclo[Ile-N(Me)Val-Leu-N(Me)Val(3-OH)-D-OxiIle-N(Me)Val-Phe-N(Me)Phe-Pro]
Formula: C60H92N8O11 (1100.6885201999999)
CAS ID: 127785-64-2
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.-.-.- | |||
| 1.1.1.102 | 3-dehydrosphinganine reductase | D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase | |
| 1.14.18.6 | 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase | (4R)-4-hydroxysphinganine ceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating) | |
| 1.14.18.7 | dihydroceramide fatty acyl 2-hydroxylase | dihydroceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating) | |
| 2.3.1.297 | very-long-chain ceramide synthase | very-long-chain fatty acyl-coA:sphingoid base N-acyltransferase | |
| 2.3.1.50 | serine C-palmitoyltransferase | palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) | |
| 2.4.1.370 | inositol phosphorylceramide mannosyltransferase | GDP-alpha-D-mannose:(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine mannosyltransferase (configuration-retaining) | |
| 2.7.1.227 | inositol phosphorylceramide synthase | 1-phosphatidyl-1D-myo-inositol:a very-long-chain (2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase | |
| 2.7.1.228 | mannosyl-inositol-phosphoceramide inositolphosphotransferase | 1-phosphatidyl-1D-myo-inositol:(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-([6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl)sphinganine phosphoinositoltransferase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P25045 | LCB1 | Serine palmitoyltransferase 1 |
| P28496 | LAC1 | Ceramide synthase LAC1 |
| P33300 | SUR1 | Mannosyl phosphorylinositol ceramide synthase SUR1 |
| P36107 | AUR1 | Inositol phosphorylceramide synthase catalytic subunit AUR1 |
| P38287 | CSH1 | Mannosyl phosphorylinositol ceramide synthase CSH1 |
| P38342 | TSC10 | 3-ketodihydrosphingosine reductase TSC10 |
| P38703 | LAG1 | Ceramide synthase LAG1 |
| P38954 | IPT1 | Inositolphosphotransferase 1 |
| P38992 | SUR2 | Sphingolipid C4-hydroxylase SUR2 |
| P40970 | LCB2 | Serine palmitoyltransferase 2 |
| Q03529 | SCS7 | Ceramide very long chain fatty acid hydroxylase SCS7 |