Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Winzell MS, Ahrén B. G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes. Pharmacol Ther. 2007 Dec;116(3):437–48. doi: 10.1016/j.pharmthera.2007.08.002. PMID: 17900700.; Doyle ME, Egan JM. Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacology & Therapeutics. 2007 Mar;113(3):546–93. doi: 10.1016/j.pharmthera.2006.11.007.; Gromada J, Brock B, Schmitz O, Rorsman P. Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential. Basic Clin Pharmacol Toxicol. 2004 Dec;95(6):252–62. doi: 10.1111/j.1742-7843.2004.t01-1-pto950502.x. PMID: 15569269.; MacDonald PE, El-Kholy W, Riedel MJ, Salapatek AM, Light PE, Wheeler MB. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes. 2002 Dec;51 Suppl 3():S434–42. doi: 10.2337/diabetes.51.2007.s434. PMID: 12475787.; Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, Schermerhorn T, Straub SG, Yajima H, Sharp GW. Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes. 2002 Feb;51 Suppl 1():S83–90. doi: 10.2337/diabetes.51.2007.s83. PMID: 11815463.; Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes. 2000 Nov;49(11):1751–60. doi: 10.2337/diabetes.49.11.1751. PMID: 11078440.; Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. European Journal of Biochemistry. 1999 Jan;259(1-2):3–17. doi: 10.1046/j.1432-1327.1999.00043.x.; GROMADA J, RORSMAN P. Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting bTC3 cells. Acta Physiologica Scandinavica. 1996 Jul;157(3):349–51. doi: 10.1046/j.1365-201x.1996.40255000.x.

Metabolites

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4



Enzyme

EC Number name full name note
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name