Gene Silencing by RNA

Ipsaro JJ, Joshua-Tor L. From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nature Structural & Molecular Biology. 2015 Jan 07;22(1):20–8. doi: 10.1038/nsmb.2931.; Ketting RF. microRNA Biogenesis and Function : An overview. Adv Exp Med Biol. 2011;700():1–14. doi: 10.1007/978-1-4419-7823-3_1. PMID: 21755468.; Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009 Feb 20;136(4):642–55. PMID: 19239886; PMCID: PMC2675692.; Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nature Reviews Molecular Cell Biology. 2009 Feb;10(2):126–39. doi: 10.1038/nrm2632.; Verdel A, Vavasseur A, Le Gorrec M, Touat-Todeschini L. Common themes in siRNA-mediated epigenetic silencing pathways. Int J Dev Biol. 2009;53(2-3):245–57. doi: 10.1387/ijdb.082691av. PMID: 19412884.; Peters L, Meister G. Argonaute proteins: mediators of RNA silencing. Mol Cell. 2007 Jun 08;26(5):611–23. doi: 10.1016/j.molcel.2007.05.001. PMID: 17560368.; Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 2006 Mar 01;20(5):515–24. doi: 10.1101/gad.1399806. PMID: 16510870.; Tomari Y, Zamore PD. Perspective: machines for RNAi. Genes Dev. 2005 Mar 01;19(5):517–29. doi: 10.1101/gad.1284105. PMID: 15741316.

Metabolites

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2



Enzyme

EC Number name full name note
2.7.7.6 DNA-directed RNA polymerase nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
3.1.26.3 ribonuclease III


Proteins

Protein ID name full name