SUMO E3 ligases SUMOylate target proteins

Jentsch S, Psakhye I. Control of nuclear activities by substrate-selective and protein-group SUMOylation. Annu Rev Genet. 2013;47():167–86. doi: 10.1146/annurev-genet-111212-133453. PMID: 24016193.; Yang XJ, Chiang CM. Sumoylation in gene regulation, human disease, and therapeutic action. F1000Prime Rep. 2013;5():45. PMID: 24273646; PMCID: PMC3816760.; Flotho A, Melchior F. Sumoylation: a regulatory protein modification in health and disease. Annu Rev Biochem. 2013;82():357–85. doi: 10.1146/annurev-biochem-061909-093311. PMID: 23746258.; Becker J, Barysch SV, Karaca S, Dittner C, Hsiao HH, Berriel Diaz M, Herzig S, Urlaub H, Melchior F. Detecting endogenous SUMO targets in mammalian cells and tissues. Nat Struct Mol Biol. 2013 Apr;20(4):525–31. doi: 10.1038/nsmb.2526. PMID: 23503365.; Citro S, Chiocca S. Sumo paralogs: redundancy and divergencies. Front Biosci (Schol Ed). 2013 Jan 01;5(2):544–53. doi: 10.2741/s388. PMID: 23277067.; Da Silva-Ferrada E, Lopitz-Otsoa F, Lang V, Rodríguez MS, Matthiesen R. Strategies to Identify Recognition Signals and Targets of SUMOylation. Biochemistry Research International. 2012;2012():1–16. doi: 10.1155/2012/875148.; Tatham MH, Matic I, Mann M, Hay RT. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Sci Signal. 2011 Jun 21;4(178):rs4. doi: 10.1126/scisignal.2001484. PMID: 21693764.; Bruderer R, Tatham MH, Plechanovova A, Matic I, Garg AK, Hay RT. Purification and identification of endogenous polySUMO conjugates. EMBO Reports. 2011 Jan 21;12(2):142–8. doi: 10.1038/embor.2010.206.; Hannoun Z, Greenhough S, Jaffray E, Hay RT, Hay DC. Post-translational modification by SUMO. Toxicology. 2010 Dec 30;278(3):288–93. doi: 10.1016/j.tox.2010.07.013. PMID: 20674646.; Gareau JR, Lima CD. The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nature Reviews Molecular Cell Biology. 2010 Nov 23;11(12):861–71. doi: 10.1038/nrm3011.; Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT. System-wide changes to SUMO modifications in response to heat shock. Sci Signal. 2009 May 26;2(72):ra24. doi: 10.1126/scisignal.2000282. PMID: 19471022.; Zhao J. Sumoylation regulates diverse biological processes. Cellular and Molecular Life Sciences. 2007 Sep 04;64(23):3017–33. doi: 10.1007/s00018-007-7137-4.; Vertegaal AC, Andersen JS, Ogg SC, Hay RT, Mann M, Lamond AI. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics. 2006 Dec;5(12):2298–310. doi: 10.1074/mcp.m600212-mcp200. PMID: 17000644.

Metabolites



Enzyme

EC Number name full name note
2.3.2.-
2.7.12.1 dual-specificity kinase ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
3.5.1.98 histone deacetylase histone amidohydrolase
3.6.4.13 RNA helicase
5.6.2.1 DNA topoisomerase DNA topoisomerase
5.6.2.2 DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase (ATP-hydrolysing)


Proteins

Protein ID name full name