Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Dianova II, Bohr VA, Dianov GL. Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Biochemistry. 2001 Oct 23;40(42):12639–44. doi: 10.1021/bi011117i. PMID: 11601988.; Prasad R, Lavrik OI, Kim SJ, Kedar P, Yang XP, Vande Berg BJ, Wilson SH. DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. J Biol Chem. 2001 Aug 31;276(35):32411–4. doi: 10.1074/jbc.c100292200. PMID: 11440997.; Lindahl T, Wood RD. Quality control by DNA repair. Science. 1999 Dec 03;286(5446):1897–905. doi: 10.1126/science.286.5446.1897. PMID: 10583946.; Matsumoto Y, Kim K, Hurwitz J, Gary R, Levin DS, Tomkinson AE, Park MS. Reconstitution of Proliferating Cell Nuclear Antigen-dependent Repair of Apurinic/Apyrimidinic Sites with Purified Human Proteins. Journal of Biological Chemistry. 1999 Nov;274(47):33703–8. doi: 10.1074/jbc.274.47.33703.; Dianov GL, Jensen BR, Kenny MK, Bohr VA. Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extracts. Biochemistry. 1999 Aug 24;38(34):11021–5. doi: 10.1021/bi9908890. PMID: 10460157.; Klungland A, Lindahl T. Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). EMBO J. 1997 Jun 02;16(11):3341–8. PMID: 9214649; PMCID: PMC1169950.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
3.1.-.-
6.5.1.1 DNA ligase (ATP) poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP)


Proteins

Protein ID name full name