APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Das A, Wiederhold L, Leppard JB, Kedar P, Prasad R, Wang H, Boldogh I, Karimi-Busheri F, Weinfeld M, Tomkinson AE, Wilson SH, Mitra S, Hazra TK. NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. DNA Repair (Amst). 2006 Dec 09;5(12):1439–48. PMID: 16982218; PMCID: PMC2805168.; Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M, Tomkinson AE, Izumi T, Prasad R, Wilson SH, Mitra S, Hazra TK. AP endonuclease-independent DNA base excision repair in human cells. Mol Cell. 2004 Jul 23;15(2):209–20. doi: 10.1016/j.molcel.2004.06.003. PMID: 15260972.; Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell. 2001 Jan 12;104(1):107–17. doi: 10.1016/s0092-8674(01)00195-7. PMID: 11163244.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5



Enzyme

EC Number name full name note
4.2.99.-
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase


Proteins

Protein ID name full name