Cilium Assembly

Nachury MV. How do cilia organize signalling cascades? Philos Trans R Soc Lond B Biol Sci. 2014 Sep 05;369(1650). PMID: 25047619; PMCID: PMC4113109.; Madhivanan K, Aguilar RC. Ciliopathies: the trafficking connection. Traffic. 2014 Oct;15(10):1031–56. PMID: 25040720; PMCID: PMC4167927.; Sung CH, Leroux MR. The roles of evolutionarily conserved functional modules in cilia-related trafficking. Nat Cell Biol. 2013 Dec;15(12):1387–97. PMID: 24296415; PMCID: PMC4016715.; Bhogaraju S, Engel BD, Lorentzen E. Intraflagellar transport complex structure and cargo interactions. Cilia. 2013 Aug 14;2(1):10. PMID: 23945166; PMCID: PMC3751104.; Reiter JF, Blacque OE, Leroux MR. The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization. EMBO Rep. 2012 Jun 29;13(7):608–18. PMID: 22653444; PMCID: PMC3388784.; Li Y, Ling K, Hu J. The emerging role of Arf/Arl small GTPases in cilia and ciliopathies. J of Cellular Biochemistry. 2012 May 09;113(7):2201–7. doi: 10.1002/jcb.24116.; Hsiao YC, Tuz K, Ferland RJ. Trafficking in and to the primary cilium. Cilia. 2012 Apr 25;1(1):4. PMID: 23351793; PMCID: PMC3541539.; Taschner M, Bhogaraju S, Lorentzen E. Architecture and function of IFT complex proteins in ciliogenesis. Differentiation. 2012 Feb;83(2):S12–22. PMID: 22118932; PMCID: PMC3977345.; Ishikawa H, Marshall WF. Ciliogenesis: building the cell's antenna. Nature Reviews Molecular Cell Biology. 2011 Mar 23;12(4):222–34. doi: 10.1038/nrm3085.; Nachury MV, Seeley ES, Jin H. Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier? Annu. Rev. Cell Dev. Biol. 2010 Nov 10;26(1):59–87. doi: 10.1146/annurev.cellbio.042308.113337.; Rohatgi R, Snell WJ. The ciliary membrane. Current Opinion in Cell Biology. 2010 Aug;22(4):541–6. doi: 10.1016/j.ceb.2010.03.010.; Goetz SC, Anderson KV. The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet. 2010 May;11(5):331–44. PMID: 20395968; PMCID: PMC3121168.; Emmer BT, Maric D, Engman DM. Molecular mechanisms of protein and lipid targeting to ciliary membranes. J Cell Sci. 2010 Feb 15;123(Pt 4):529–36. PMID: 20145001; PMCID: PMC2818192.; Berbari NF, O'Connor AK, Haycraft CJ, Yoder BK. The Primary Cilium as a Complex Signaling Center. Current Biology. 2009 Jul;19(13):R526–35. doi: 10.1016/j.cub.2009.05.025.; Fliegauf M, Benzing T, Omran H. When cilia go bad: cilia defects and ciliopathies. Nature Reviews Molecular Cell Biology. 2007 Nov;8(11):880–93. doi: 10.1038/nrm2278.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2



Enzyme

EC Number name full name note
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name