globo-series glycosphingolipids biosynthesis

Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N. Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. J Biol Chem. 1998 May 29;273(22):13570–7. doi: 10.1074/jbc.273.22.13570. PMID: 9593693.; Chatterjee S, Ghosh N, Khurana S. Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney. Journal of Biological Chemistry. 1992 Apr;267(10):7148–53. doi: 10.1016/s0021-9258(19)50550-6.; Chatterjee S, Castiglione E. UDPgalactose:glucosylceramide ß1 ? 4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes. Biochimica et Biophysica Acta (BBA) - General Subjects. 1987 Jan;923(1):136–42. doi: 10.1016/0304-4165(87)90136-x.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Trihexosylceramide (d18:1/22:0)

Formula: C58H109NO18 (1107.7644254)

CAS ID:

Tetrahexosylceramide (d18:1/26:0)

Formula: C70H130N2O23 (1366.906391)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
2.4.1.274 glucosylceramide beta-1,4-galactosyltransferase UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase
2.4.1.344 type 2 galactoside alpha-(1,2)-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
2.4.1.80 ceramide glucosyltransferase UDP-glucose:N-acylsphingosine D-glucosyltransferase
2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase CMP-N-acetyl-beta-neuraminate:a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R alpha-(2->3)-N-acetylneuraminyltransferase (configuration-inverting)
2.4.3.4 beta-galactoside alpha-2,3-sialyltransferase CMP-N-acetylneuraminate:beta-D-galactoside alpha-(2->3)-N-acetylneuraminyl-transferase


Proteins

Protein ID name full name