SUMOylation of DNA damage response and repair proteins

Flotho A, Melchior F. Sumoylation: a regulatory protein modification in health and disease. Annu Rev Biochem. 2013;82():357–85. doi: 10.1146/annurev-biochem-061909-093311. PMID: 23746258.; Jackson SP, Durocher D. Regulation of DNA damage responses by ubiquitin and SUMO. Mol Cell. 2013 Mar 07;49(5):795–807. doi: 10.1016/j.molcel.2013.01.017. PMID: 23416108.; Bologna S, Ferrari S. It takes two to tango: Ubiquitin and SUMO in the DNA damage response. Front Genet. 2013;4():106. PMID: 23781231; PMCID: PMC3678106.; Psakhye I, Jentsch S. Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair. Cell. 2012 Nov 09;151(4):807–20. doi: 10.1016/j.cell.2012.10.021. PMID: 23122649.; Cremona CA, Sarangi P, Zhao X. Sumoylation and the DNA damage response. Biomolecules. 2012 Sep;2(3):376–88. PMID: 24926426; PMCID: PMC4030838.; Ulrich HD. Ubiquitin and SUMO in DNA repair at a glance. J Cell Sci. 2012 Jan 15;125(Pt 2):249–54. doi: 10.1242/jcs.091801. PMID: 22357966.; Praefcke GJ, Hofmann K, Dohmen RJ. SUMO playing tag with ubiquitin. Trends Biochem Sci. 2012 Jan;37(1):23–31. doi: 10.1016/j.tibs.2011.09.002. PMID: 22018829.; van Wijk SJ, Müller S, Dikic I. Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair. Genes Dev. 2011 Sep 01;25(17):1763–9. PMID: 21896653; PMCID: PMC3175713.; Bekker-Jensen S, Mailand N. The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks. FEBS Lett. 2011 Sep 16;585(18):2914–9. doi: 10.1016/j.febslet.2011.05.056. PMID: 21664912.; Dou H, Huang C, Van Nguyen T, Lu LS, Yeh ET. SUMOylation and de-SUMOylation in response to DNA damage. FEBS Lett. 2011 Sep 16;585(18):2891–6. doi: 10.1016/j.febslet.2011.04.002. PMID: 21486569.

Metabolites



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)


Proteins

Protein ID name full name