Events associated with phagocytolytic activity of PMN cells

Winterbourn CC, Kettle AJ, Hampton MB. Reactive Oxygen Species and Neutrophil Function. Annu Rev Biochem. 2016 Jun 02;85():765–92. doi: 10.1146/annurev-biochem-060815-014442. PMID: 27050287.; Levine AP, Duchen MR, de Villiers S, Rich PR, Segal AW. Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity. PLoS ONE. 2015 Apr 17;10(4):e0125906. doi: 10.1371/journal.pone.0125906.; Winterbourn CC, Kettle AJ. Redox reactions and microbial killing in the neutrophil phagosome. Antioxid Redox Signal. 2013 Feb 20;18(6):642–60. doi: 10.1089/ars.2012.4827. PMID: 22881869.; Demaurex N, El Chemaly A. Physiological roles of voltage-gated proton channels in leukocytes. J Physiol. 2010 Dec 01;588(Pt 23):4659–65. PMID: 20693294; PMCID: PMC3010135.; Petheo GL, Orient A, Baráth M, Kovács I, Réthi B, Lányi Á, Rajki A, Rajnavölgyi É, Geiszt M. Molecular and Functional Characterization of Hv1 Proton Channel in Human Granulocytes. PLoS ONE. 2010 Nov 23;5(11):e14081. doi: 10.1371/journal.pone.0014081.; El Chemaly A, Okochi Y, Sasaki M, Arnaudeau S, Okamura Y, Demaurex N. VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification. J Exp Med. 2010 Jan 18;207(1):129–39. PMID: 20026664; PMCID: PMC2812533.; Henderson LM, Chappell JB, Jones OT. Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge. Biochem J. 1988 Oct 01;255(1):285–90. PMID: 2848506; PMCID: PMC1135221.; Henderson LM, Chappell JB, Jones OT. The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem J. 1987 Sep 01;246(2):325–9. PMID: 2825632; PMCID: PMC1148280.

Metabolites

Cl-

Formula: Cl (34.968853)

CAS ID: 16887-00-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Hypochlorous acid

Formula: HClO (51.9715926)

CAS ID: 7790-92-3

Thiocyanate

Formula: CNS (57.975145999999995)

CAS ID: 302-04-5

Hypothiocyanite

Formula: CHNOS (74.9778856)

CAS ID: 63296-34-4

nitrite

Formula: NO2 (45.992904)

CAS ID: 14797-65-0



Enzyme

EC Number name full name note


Proteins

Protein ID name full name