Complex IV assembly

Dennerlein S, Rehling P, Richter-Dennerlein R. Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1. FEBS Letters. 2023 May 31;597(12):1569–78. doi: 10.1002/1873-3468.14671.; Nývltová E, Dietz JV, Seravalli J, Khalimonchuk O, Barrientos A. Coordination of metal center biogenesis in human cytochrome c oxidase. Nature Communications. 2022 Jun 24;13(1):3615. doi: 10.1038/s41467-022-31413-1.; Cunátová K, Pajuelo Reguera D, Houštek J, Mrácek T, Pecina P. Role of cytochrome c oxidase nuclear-encoded subunits in health and disease. Physiol Res. 2020 Nov 02;():947–65. doi: 10.33549/physiolres.934446.; Watson SA, McStay GP. Functions of Cytochrome c oxidase Assembly Factors. Int J Mol Sci. 2020 Sep 30;21(19). PMID: 33008142; PMCID: PMC7582755.; Zong S, Wu M, Gu J, Liu T, Guo R, Yang M. Structure of the intact 14-subunit human cytochrome c oxidase. Cell Research. 2018 Jul 20;28(10):1026–34. doi: 10.1038/s41422-018-0071-1.; Timón-Gómez A, Nývltová E, Abriata LA, Vila AJ, Hosler J, Barrientos A. Mitochondrial cytochrome c oxidase biogenesis: Recent developments. Seminars in Cell & Developmental Biology. 2018 Apr;76():163–78. doi: 10.1016/j.semcdb.2017.08.055.; Mick DU, Fox TD, Rehling P. Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation. Nature Reviews Molecular Cell Biology. 2010 Dec 22;12(1):14–20. doi: 10.1038/nrm3029.; Pecina P, Houštková H, Zeman J, Houštek J. Genetic defects of cytochrome c oxidase assembly. Physiol Res. 2004;():S213–23. doi: 10.33549/physiolres.930000.53.s213.

Metabolites

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Cu+

Formula: Cu (62.929599)

CAS ID: 17493-86-6

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ferriheme a3(1-)

Formula: C49H60FeN4O6 (856.386201)

CAS ID: 58916-42-0



Enzyme

EC Number name full name note
1.17.99.9 heme a synthase ferroheme o:acceptor C-81-oxidoreductase (heme a-forming)
7.1.1.9 cytochrome-c oxidase ferrocytochrome-c:oxygen oxidoreductase


Proteins

Protein ID name full name