Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence

Goding CR, Arnheiter H. MITF-the first 25 years. Genes Dev. 2019 Aug 01;33(15-16):983–1007. PMID: 31123060; PMCID: PMC6672050.; Seoane M, Buhs S, Iglesias P, Strauss J, Puller AC, Müller J, Gerull H, Feldhaus S, Alawi M, Brandner JM, Eggert D, Du J, Thomale J, Wild PJ, Zimmermann M, Sternsdorf T, Schumacher U, Nollau P, Fisher DE, Horstmann MA. Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair. Oncogene. 2019 May;38(19):3616–35. PMID: 30651597; PMCID: PMC6756118.; Falletta P, Sanchez-Del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, Siddaway R, Lisle R, Freter R, Daniels MJ, Lu X, Tüting T, Middleton M, Buffa FM, Willis AE, Pavitt G, Ronai ZA, Sauka-Spengler T, Hölzel M, Goding CR. Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma. Genes Dev. 2017 Jan 01;31(1):18–33. PMID: 28096186; PMCID: PMC5287109.; Strub T, Giuliano S, Ye T, Bonet C, Keime C, Kobi D, Le Gras S, Cormont M, Ballotti R, Bertolotto C, Davidson I. Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011 May 19;30(20):2319–32. doi: 10.1038/onc.2010.612. PMID: 21258399.; Giuliano S, Cheli Y, Ohanna M, Bonet C, Beuret L, Bille K, Loubat A, Hofman V, Hofman P, Ponzio G, Bahadoran P, Ballotti R, Bertolotto C. Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas. Cancer Res. 2010 May 01;70(9):3813–22. doi: 10.1158/0008-5472.can-09-2913. PMID: 20388797.; Cheli Y, Ohanna M, Ballotti R, Bertolotto C. Fifteen-year quest for microphthalmia-associated transcription factor target genes. Pigment Cell Melanoma Res. 2010 Feb;23(1):27–40. doi: 10.1111/j.1755-148x.2009.00653.x. PMID: 19995375.

Metabolites



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.7.49 RNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)
3.6.4.12 DNA helicase
6.5.1.1 DNA ligase (ATP) poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP)


Proteins

Protein ID name full name