Formation of the ureteric bud

McMahon AP. Development of the Mammalian Kidney. Curr Top Dev Biol. 2016;117():31–64. PMID: 26969971; PMCID: PMC5007134.; Wainwright EN, Wilhelm D, Combes AN, Little MH, Koopman P. ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015 Aug 15;404(2):88–102. doi: 10.1016/j.ydbio.2015.05.023. PMID: 26116176.; Marcotte M, Sharma R, Bouchard M. Gene regulatory network of renal primordium development. Pediatr Nephrol. 2014 Apr;29(4):637–44. doi: 10.1007/s00467-013-2635-0. PMID: 24104595.; Costantini F. Genetic controls and cellular behaviors in branching morphogenesis of the renal collecting system. Wiley Interdiscip Rev Dev Biol. 2012 Sep;1(5):693–713. PMID: 22942910; PMCID: PMC3430146.; Linton JM, Martin GR, Reichardt LF. The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Development. 2007 Jul;134(13):2501–9. PMID: 17537792; PMCID: PMC2757411.; Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP. Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development. 2003 Jul;130(14):3175–85. doi: 10.1242/dev.00520. PMID: 12783789.; Brandenberger R, Schmidt A, Linton J, Wang D, Backus C, Denda S, Müller U, Reichardt LF. Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. J Cell Biol. 2001 Jul 23;154(2):447–58. PMID: 11470831; PMCID: PMC2150762.; Trupp M, Arenas E, Fainzilber M, Nilsson A, Sieber B, Grigoriou M, Kilkenny C, Salazar-Grueso E, Pachnis V, Arumäe U, Sariola H, Saarma M, Ibáñez CF. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature. 1996 Jun;381(6585):785–9. doi: 10.1038/381785a0.

Metabolites



Enzyme

EC Number name full name note
2.7.10.1 receptor protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase


Proteins

Protein ID name full name